abstract：:Spinal cord injury (SCI) is a tragic event causing irreversible losses of sensory, motor, and autonomic functions, that may also be associated with chronic neuropathic pain. Serotonin (5-HT) neurotransmission in the spinal cord is critical for modulating sensory, motor, and autonomic functions. Following SCI, 5-HT axo...

journal_title：Experimental neurology

authors： Perrin FE,Noristani HN

更新日期：2019-08-01 00:00:00

abstract：:Dopaminergic (DAergic) hypofunction in the medial prefrontal cortex (mPFC) has been implicated in the negative and cognitive symptoms of schizophrenia and is regulated by serotonergic (5-HTergic) neurons in the dorsal raphe nucleus (DRN). The lateral habenula (LHb) is a key element in controlling DRN 5-HT neurons. We ...

journal_title：Experimental neurology

authors： Li J,Yang S,Liu X,Han Y,Li Y,Feng J,Zhao H

更新日期：2019-08-01 00:00:00

abstract：:The response of the developing brain to traumatic injury is different from the response of the mature, adult brain. There are critical developmental trajectories in the young brain, whereby injury can lead to long term functional abnormalities. Emerging preclinical and clinical literature supports the presence of sign...

journal_title：Experimental neurology

authors： Arambula SE,Reinl EL,El Demerdash N,McCarthy MM,Robertson CL

更新日期：2019-07-01 00:00:00

abstract：:In mammals, free d-aspartate (D-Asp) is abundant in the embryonic brain, while levels remain very low during adulthood as a result of the postnatal expression and activity of the catabolizing enzyme d-aspartate oxidase (DDO). Previous studies have shown that long-lasting exposure to nonphysiological, higher D-Asp conc...

journal_title：Experimental neurology

authors： Nuzzo T,Feligioni M,Cristino L,Pagano I,Marcelli S,Iannuzzi F,Imperatore R,D'Angelo L,Petrella C,Carella M,Pollegioni L,Sacchi S,Punzo D,De Girolamo P,Errico F,Canu N,Usiello A

更新日期：2019-07-01 00:00:00

abstract：:The blood-brain barrier (BBB) constitutes a neurovascular unit formed by microvascular endothelial cells, pericytes, and astrocytes. Brain pericytes are important regulators of BBB integrity, permeability, and blood flow. Pericyte loss has been implicated in injury; however, how the crosstalk among pericytes, endothel...

journal_title：Experimental neurology

authors： Bhowmick S,D'Mello V,Caruso D,Wallerstein A,Abdul-Muneer PM

更新日期：2019-07-01 00:00:00

abstract：:An estimated 2.8 million traumatic brain injuries (TBI) occur within the United States each year. Approximately 40% of new TBI cases are female, however few studies have investigated the effects of TBI on female subjects. In addition to typical neurobehavioral sequelae observed after TBI, such as poor cognition, impai...

journal_title：Experimental neurology

authors： Fortress AM,Avcu P,Wagner AK,Dixon CE,Pang KCH

更新日期：2019-05-01 00:00:00

abstract：:Typical antipsychotic drugs (APDs) with D2antagonistic properties impede functional outcome after experimental traumatic brain injury (TBI) and reduce the effectiveness of environmental enrichment (EE). Here we test the hypothesis that aripiprazole (ARIP), an atypical APD with partial D2and 5-HT1Areceptor agonist acti...

journal_title：Experimental neurology

authors： Besagar S,Radabaugh HL,Bleimeister IH,Meyer EA,Niesman PJ,Cheng JP,Bondi CO,Kline AE

更新日期：2019-04-01 00:00:00

abstract：:Focal limbic seizures often impair consciousness/awareness with major negative impact on quality of life. Recent work has shown that limbic seizures depress brainstem arousal systems, including reduced action potential firing in a key node: cholinergic neurons of the pedunculopontine tegmental nucleus (PPT). In vivo w...

journal_title：Experimental neurology

authors： Andrews JP,Yue Z,Ryu JH,Neske G,McCormick DA,Blumenfeld H

更新日期：2019-04-01 00:00:00

abstract：:Ischemic stroke is an acute neurodegenerative disease that is extremely devastating to patients, their families and society. Stroke is inadequately treated even with endovascular procedures and reperfusion therapy. Using an extensive translational screening process, we have developed a pleiotropic cytoprotective agent...

journal_title：Experimental neurology

authors： Lapchak PA,Boitano PD,Bombien R,Cook DJ,Doyan S,Lara JM,Schubert DR

更新日期：2019-03-01 00:00:00

abstract：:It has been >20 years since studies first revealed that the brain is insulin sensitive, highlighted by the expression of insulin receptors in neurons and glia, the presence of circulating brain insulin, and even localized insulin production. Following these discoveries, evidence of decreased brain insulin receptor num...

journal_title：Experimental neurology

authors： Frazier HN,Ghoweri AO,Anderson KL,Lin RL,Porter NM,Thibault O

更新日期：2019-03-01 00:00:00

abstract：:Because vitamin D hormone deficiency (VDHdef) can worsen severity and outcome for ischemic stroke, we examined the role of VDH in maintaining blood-brain-barrier (BBB integrity) in a rat model of stroke. In most types of stroke, the BBB is markedly compromised, potentially leading to a cascade of injury processes and ...

journal_title：Experimental neurology

authors： Sayeed I,Turan N,Stein DG,Wali B

更新日期：2019-02-01 00:00:00

abstract：:Our previous studies showed that Insulin-like Growth Factor (IGF)-1 reduced blood brain barrier permeability and decreased infarct volume caused by middle cerebral artery occlusion (MCAo) in middle aged female rats. Similarly, cultures of primary brain microvessel endothelial cells from middle-aged female rats and exp...

journal_title：Experimental neurology

authors： Bake S,Okoreeh A,Khosravian H,Sohrabji F

更新日期：2019-01-01 00:00:00

abstract：:Dravet syndrome is a severe, early-onset epileptic encephalopathy frequently resulting from de novo mutations of SCN1A. Mice with heterozygous deletion of Scn1a (Scn1a+/-) model many features of Dravet syndrome, including spontaneous seizures and premature lethality. Scn1a+/- mice exhibit variable phenotype penetrance...

journal_title：Experimental neurology

authors： Hawkins NA,Calhoun JD,Huffman AM,Kearney JA

更新日期：2019-01-01 00:00:00

abstract：:Accumulating evidence shows alterations in the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) in ALS patients and in animal models of disease, mainly by endothelial cell (EC) damage. Repair of the altered barrier in the CNS by replacement of ECs via cell transplantation may be a new therapeutic approac...

journal_title：Experimental neurology

authors： Garbuzova-Davis S,Haller E,Navarro S,Besong TE,Boccio KJ,Hailu S,Khatib M,Sanberg PR,Appel SH,Borlongan CV

更新日期：2018-12-01 00:00:00

abstract：:The focus of this study is the expression of Toll-like receptor-3 (TLR-3), a receptor for double-stranded RNA, in human brains affected by Alzheimer's disease (AD) pathology. Toll-like receptors are a family of pattern recognition molecules primarily involved in host defenses to microbial pathogens, but roles in neuro...

journal_title：Experimental neurology

authors： Walker DG,Tang TM,Lue LF

更新日期：2018-11-01 00:00:00

abstract：:SCI is followed by dramatic upregulation of chondroitin sulfate proteoglycans (CSPGs) which limit axonal regeneration, oligodendrocyte replacement and remyelination. The recent discovery of the specific CSPGs signaling receptor protein tyrosine phosphatase sigma (RPTPσ) provided an opportunity to refine the therapeuti...

journal_title：Experimental neurology

authors： Rink S,Arnold D,Wöhler A,Bendella H,Meyer C,Manthou M,Papamitsou T,Sarikcioglu L,Angelov DN

更新日期：2018-11-01 00:00:00

abstract：:Recovery from injury to the central nervous system (CNS) is limited in the mammalian adult. Nonetheless, some degree of spontaneous recovery occurs after partial CNS injury. Compensatory axonal growth from uninjured neurons, termed sprouting, contributes to this naturally occurring recovery process and can be modulate...

journal_title：Experimental neurology

authors： Meves JM,Geoffroy CG,Kim ND,Kim JJ,Zheng B

更新日期：2018-11-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) are unique glia that support axon outgrowth in the olfactory system, and when used as cellular therapy after spinal cord injury, improve recovery and axon regeneration. Here we assessed the effects of combining OEC transplantation with another promising therapy, epidural electrical s...

journal_title：Experimental neurology

authors： Thornton MA,Mehta MD,Morad TT,Ingraham KL,Khankan RR,Griffis KG,Yeung AK,Zhong H,Roy RR,Edgerton VR,Phelps PE

更新日期：2018-11-01 00:00:00

abstract：:We have analyzed a mouse model of Charcot-Marie-Tooth disease 2E (CMT2E) harboring a heterozygous p.Asn98Ser (p.N98S) Nefl mutation, whose human counterpart results in a severe, early-onset neuropathy. Behavioral, electrophysiological, and pathological analyses were done on separate cohorts of NeflN98S/+ mutant mice a...

journal_title：Experimental neurology

authors： Lancaster E,Li J,Hanania T,Liem R,Scheideler MA,Scherer SS

更新日期：2018-10-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset, fatal neurodegenerative syndrome characterized by the systemic loss of motor neurons with prominent astrocytosis and microgliosis in the spinal cord and brain. Astrocytes play an essential role in maintaining extracellular microenvironments that surround motor neu...

journal_title：Experimental neurology

authors： Shijo T,Warita H,Suzuki N,Ikeda K,Mitsuzawa S,Akiyama T,Ono H,Nishiyama A,Izumi R,Kitajima Y,Aoki M

更新日期：2018-09-01 00:00:00

abstract：:Intractable pain is the single most common cause of disability, affecting more than 20% of the population world-wide. There is accordingly a global effort to decipher how changes in nociceptive processing in the peripheral and central nervous systems contribute to the onset and maintenance of chronic pain. The past se...

journal_title：Experimental neurology

authors： Xie YF,Wang J,Bonin RP

更新日期：2018-08-01 00:00:00

abstract：:Neonatal hypoxia-ischemia (HI) is the most common cause of brain injury in neonates, which leads to high neonatal mortality and severe neurological morbidity in later life (Vannucci, 2000; Volpe, 2001). Yet the molecular mechanisms of neuronal death and brain damage induced by neonatal HI remain largely elusive. Herei...

journal_title：Experimental neurology

authors： Ma Q,Zhang L

更新日期：2018-06-01 00:00:00

abstract：:Triggering receptor expressed on myeloid cells-2 (TREM2) was a newly identified receptor expressed on microglia. Several observations support the hypothesis that TREM2 variation may confer susceptibility to Parkinson's disease (PD). Therefore, in this paper, we explored the role of TREM2 in the 1-methyl-4-phenyl-1,2,3...

journal_title：Experimental neurology

authors： Ren M,Guo Y,Wei X,Yan S,Qin Y,Zhang X,Jiang F,Lou H

更新日期：2018-04-01 00:00:00

abstract：:A complex propriospinal network is synaptically coupled to phrenic and intercostal motoneurons, and this makes it difficult to predict how gray matter intraspinal microstimulation (ISMS) will recruit respiratory motor units. We therefore mapped the cervical and high thoracic gray matter at locations which ISMS activat...

journal_title：Experimental neurology

authors： Sunshine MD,Ganji CN,Reier PJ,Fuller DD,Moritz CT

更新日期：2018-04-01 00:00:00

abstract：:Children who are born preterm are at risk for encephalopathy of prematurity, a leading cause of cerebral palsy, cognitive delay and behavioral disorders. Current interventions are limited and none have been shown to reverse cognitive and behavioral impairments, a primary determinant of poor quality of life for these c...

journal_title：Experimental neurology

authors： Robinson S,Corbett CJ,Winer JL,Chan LAS,Maxwell JR,Anstine CV,Yellowhair TR,Andrews NA,Yang Y,Sillerud LO,Jantzie LL

更新日期：2018-04-01 00:00:00

abstract：:Urethane-induced cortical slow wave activity (SWA) spreads into the basal ganglia in dopamine (DA)-depleted rat models of Parkinson's disease (PD). During physiological sleep, SWA is powerfully expressed at the beginning of night and progressively reduced during sleep-time reflecting the sleep need. However, its under...

journal_title：Experimental neurology

authors： Galati S,Song W,Orban G,Luft AR,Kaelin-Lang A

更新日期：2018-03-01 00:00:00

abstract：:Zebrafish is an excellent model to study central nervous system (CNS) axonal degeneration and regeneration since we can observe these processes in vivo and in real time in transparent larvae. Previous studies have shown that Mauthner cell (M-cell) axon regenerates poorly after mechanical spinal cord injury. Inconsiste...

journal_title：Experimental neurology

authors： Hu BB,Chen M,Huang RC,Huang YB,Xu Y,Yin W,Li L,Hu B

更新日期：2018-02-01 00:00:00

abstract：:Pericytes are a major component of cerebrovasculature playing a key role in maintaining cerebrovascular homeostasis. These cells have also been suggested to regulate brain metabolism of amyloid-β (Aβ), disturbances of which are believed to contribute to the pathogenesis of Alzheimer's disease (AD). To examine the effe...

journal_title：Experimental neurology

authors： Tachibana M,Yamazaki Y,Liu CC,Bu G,Kanekiyo T

更新日期：2018-02-01 00:00:00

abstract：:Given the prevalence and societal impact of autism spectrum disorders (ASD), there is an urgent need to develop innovative preventative strategies and treatments to reduce the alarming number of cases and improve core symptoms for afflicted individuals. Translational efforts between clinical and preclinical research a...

journal_title：Experimental neurology

authors： Bauman MD,Schumann CM

更新日期：2018-01-01 00:00:00

abstract：:This study characterizes the impact of increasing-intensity treadmill exercise (iTR) on noradrenergic (NE) and serotonergic (5HT) modulation of neuropathic pain. Following sciatic nerve transection and repair (SNTR) rats developed significant mechanical and thermal hyperalgesia that was partially prevented by iTR perf...

journal_title：Experimental neurology

authors： Lopez-Alvarez VM,Puigdomenech M,Navarro X,Cobianchi S

更新日期：2018-01-01 00:00:00

abstract：:Recent work has indicated that photobiomodulation (PBM) may beneficially alter the pathological status of several neurological disorders, although the mechanism currently remains unclear. The current study was designed to investigate the beneficial effect of PBM on behavioral deficits and neurogenesis in a photothromb...

journal_title：Experimental neurology

authors： Yang L,Tucker D,Dong Y,Wu C,Lu Y,Li Y,Zhang J,Liu TC,Zhang Q

更新日期：2018-01-01 00:00:00

abstract：:Disease-modifying treatments remain an unmet medical need in Parkinson's disease (PD). Such treatments can be operationally defined as interventions that slow down the clinical evolution to advanced disease milestones. A treatment may achieve this outcome by either inhibiting primary neurodegenerative events ("neuropr...

journal_title：Experimental neurology

authors： Francardo V,Schmitz Y,Sulzer D,Cenci MA

更新日期：2017-12-01 00:00:00

abstract：:Neuronal apoptosis is a central pathological process in subarachnoid hemorrhage (SAH)-induced early brain injury. Previous studies indicated that ErbB4 (EGFR family member v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) is essential for normal development and maintenance of the nervous system. In this...

journal_title：Experimental neurology

authors： Yan F,Tan X,Wan W,Dixon BJ,Fan R,Enkhjargal B,Li Q,Zhang J,Chen G,Zhang JH

更新日期：2017-11-01 00:00:00

abstract：:Traumatic brain injuries (TBI) sustained during peri-adolescent development produce lasting neuro-behavioral changes that render individuals at an increased risk for developing substance abuse disorders. Experimental and clinical evidence of a prolonged period of hypodopaminergia after TBI have been well documented, b...

journal_title：Experimental neurology

authors： Karelina K,Gaier KR,Weil ZM

更新日期：2017-11-01 00:00:00

abstract：:Cervical injuries are the most common form of SCI. In this study, we used a neuromodulatory approach to promote skilled movement recovery and repair of the corticospinal tract (CST) after a moderately severe C4 midline contusion in adult rats. We used bilateral epidural intermittent theta burst (iTBS) electrical stimu...

journal_title：Experimental neurology

authors： Zareen N,Shinozaki M,Ryan D,Alexander H,Amer A,Truong DQ,Khadka N,Sarkar A,Naeem S,Bikson M,Martin JH

更新日期：2017-11-01 00:00:00

abstract：:Neural progenitor cells (NPCs) grafted to sites of spinal cord injury (SCI) extend numerous axons over long distances and form new synaptic connections with host neurons. In the present study we examined the myelination of axons emerging from NPC grafts. Rat embryonic day 14 (E14) multipotent NPCs constitutively expre...

journal_title：Experimental neurology

authors： Hunt M,Lu P,Tuszynski MH

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Cognitive impairment in humans with Alzheimer's disease (AD) and in animal models of Aβ-pathology can be ameliorated by treatments with the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARγ) agonists, such as rosiglitazone (RSG). Previously, we demonstrated that in the Tg2576 animal mo...

journal_title：Experimental neurology

authors： Hsu WJ,Wildburger NC,Haidacher SJ,Nenov MN,Folorunso O,Singh AK,Chesson BC,Franklin WF,Cortez I,Sadygov RG,Dineley KT,Rudra JS,Taglialatela G,Lichti CF,Denner L,Laezza F

更新日期：2017-09-01 00:00:00

abstract：:The basis for neuronal dysfunction following inflammatory demyelination of the central nervous system (CNS) remains poorly understood. We characterized the network response to white matter injury in the anterior visual pathway using an experimental model of optic neuritis (ON), as ON is often an early manifestation of...

journal_title：Experimental neurology

authors： Wright PW,Archambault AS,Peek S,Bauer AQ,Culican SM,Ances BM,Culver JP,Wu GF

更新日期：2017-09-01 00:00:00

abstract：:Posttraumatic stress disorder (PTSD), chronic psychological stress, and major depressive disorder have been found to be associated with a significant decrease in glial fibrillary acidic protein (GFAP) immunoreactivity in the hippocampus of rodents. Cotinine is an alkaloid that prevents memory impairment, depressive-li...

journal_title：Experimental neurology

authors： Perez-Urrutia N,Mendoza C,Alvarez-Ricartes N,Oliveros-Matus P,Echeverria F,Grizzell JA,Barreto GE,Iarkov A,Echeverria V

更新日期：2017-09-01 00:00:00

abstract：:Ventral root avulsion (VRA) triggers a strong glial reaction which contributes to neuronal loss, as well as to synaptic detachment. To overcome the degenerative effects of VRA, treatments with neurotrophic factors and stem cells have been proposed. Thus, we investigated neuroprotection elicited by human embryonic stem...

journal_title：Experimental neurology

authors： Araújo MR,Kyrylenko S,Spejo AB,Castro MV,Ferreira Junior RS,Barraviera B,Oliveira ALR

更新日期：2017-08-01 00:00:00